IJTR · 2025

Full thickness placental membrane allograft for diabetic foot ulcers

Serena, T., Chashnikova, E., Tramelli, B., King, E., Shi, D., Bohn, G., & Ohse, H.

International Journal of Tissue Repair (IJTR), two clinical cases, TIGERCAMP trial

In brief

This report describes two patients with chronic diabetic foot ulcers enrolled in the ongoing randomized controlled TIGERCAMP platform trial who received weekly applications of a full-thickness placental membrane allograft (caregraFT) alongside standard care, including offloading with a removable walker boot. Both wounds achieved complete closure, one at Week 9 and the other at Week 8, with closure confirmed at subsequent follow-up visits. No product-related adverse events were reported. As a report of two clinical cases, these findings do not establish effectiveness, and the authors emphasize the need for continued evaluation in controlled studies.

SerenaGroup ran the TIGERCAMP trial these cases come from.

Plain-language summary by SerenaGroup. See the full text for complete methods and results.

Abstract

Keywords

Interim analysisdiabetic foot ulcerschronic woundswound coveringwound closuretissue regenerationcellular acellular matrix-like productsplatform trialcase studyclinical trial design

Full thickness placental membrane allograft for diabetic foot ulcers

In brief

Abstract

Keywords

Related in Human Amnion Chorion Membrane Studies & Treatments