Publications library Research article
Wound Repair Regen · 2014
Serena, T.E., Carter, M.J., Le, L.T., Sabo, M.J., DiMarco, D.T., & the EpiFix VLU Study Group
Wound Repair and Regeneration, 2014
This multicenter, randomized, open-label trial compared one or two applications of dehydrated human amnion/chorion membrane allograft (EpiFix) plus multilayer compression with multilayer compression alone in 84 patients with venous leg ulcers, with a primary outcome of at least 40% wound closure at 4 weeks. The primary outcome was reached by 33/53 (62%) allograft-treated patients versus 10/31 (32%) controls, a statistically significant difference (p = 0.005), and mean wound size reduction at 4 weeks was 48.1% versus 19.0%. The 4-week endpoint is a surrogate for complete healing, which was not assessed in this report.
Dr. Thomas Serena of SerenaGroup was the trial's lead investigator and first author.
Plain-language summary by SerenaGroup. See the full text for complete methods and results.
No abstract is published for this item. Use the full text link for the complete document.
