IJTR · 2025

Evaluation of amnion chorion amnion placental allograft in the management of nonhealing diabetic foot ulcers and venous leg ulcers

Serena, T., McGurk, S., Tramelli, B., King, E., Shi, D., Bohn, G., & Ohse, H.

International Journal of Tissue Repair (IJTR), preliminary case series, TIGERCAMP trial

In brief

This preliminary case series describes three patients enrolled in the TIGERCAMP clinical trial, two with venous leg ulcers and one with a diabetic foot ulcer, whose wounds had not closed after four weeks of standard care. Following treatment with an amnion chorion amnion placental allograft (ACAPatch) alongside standard care, all three wounds achieved complete closure at weeks 5, 9, and 12, respectively. No product-related adverse events were reported. These preliminary findings warrant further evaluation in controlled studies to confirm efficacy.

SerenaGroup ran the TIGERCAMP trial these cases come from.

Plain-language summary by SerenaGroup. See the full text for complete methods and results.

Abstract

Evaluation of amnion chorion amnion placental allograft in the management of nonhealing diabetic foot ulcers and venous leg ulcers: a preliminary case series of the TIGERCAMP clinical trial Thomas Serena1 MD | Siobhan McGurk1 | Brianna Tramelli1 | Emily King1 MS | Dereck Shi1 MS | Gregory Bohn1 MD | Henry Ohse1 1 SerenaGroup, Inc., Cambridge, MA

Keywords

Interim analysisdiabetic foot ulcervenous leg ulcerchronic woundswound coveringwound closurecellular acellular matrix-like productsplatform trialcase studyclinical trial design

Evaluation of amnion chorion amnion placental allograft in the management of nonhealing diabetic foot ulcers and venous leg ulcers

In brief

Abstract

Keywords

Related in Human Amnion Chorion Membrane Studies & Treatments