Publications library Research article
CWCMR · 2026
Serena, T.E., Tramelli, B., Cook, E., Shi, D., Bohn, G., & Breisinger, R.
Journal of Chronic Wound Care Management and Research (CWCMR)
This interim analysis of CAMPX, a randomized controlled trial at 19 US centers, compared a single-layer amniotic membrane (SLAM) plus standard of care with standard of care alone for chronic diabetic foot ulcers over 12 weeks. Among 129 randomized patients, complete wound closure occurred in 17.9% of those receiving SLAM plus standard care compared with 11.3% receiving standard care alone; in the per-protocol population, closure rates were 31.2% and 21.4%, respectively. The SLAM group also showed a greater median reduction in wound area. These differences were not statistically significant at this stage, and the authors describe the results as a preliminary trend that needs confirmation in the final analysis. The trial was funded by Applied Biologics, maker of the membrane.
SerenaGroup ran this trial for Applied Biologics.
Plain-language summary by SerenaGroup. See the full text for complete methods and results.
No abstract is published for this item. Use the full text link for the complete document.
